4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10270501, compound

HRID 1435631Notes

Reaction equation

HRID 1435631 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][O:14][C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[CH:17][C:16]=1[S:22](Cl)(=[O:24])=[O:23]>>[CH3:13][O:14][C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[CH:17][C:16]=1[S:22]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:23])=[O:24]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 113450482-Methoxy-4-methylbenzene-1-sulfonyl chloride

Product 1

HCID 10270501HCID 10270501, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-methoxy-4-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (2.3 mg) with purity >90%. LCMS (pos) m/z 371.2.

Sources & evidence

ORD record
ord-0d4ff015e4fd41fdaa32cb51b77bba57
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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