4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10178794, compound

HRID 1435632Notes

Reaction equation

HRID 1435632 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:15]=[C:16]([S:21](Cl)(=[O:23])=[O:22])[CH:17]=[C:18]([Cl:20])[CH:19]=1>>[Cl:20][C:18]1[CH:17]=[C:16]([S:21]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:23])[CH:15]=[C:14]([Cl:13])[CH:19]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 5223883,5-Dichlorobenzenesulfonyl chloride

Product 1

HCID 10178794HCID 10178794, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3,5-dichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (42.2 mg) with purity >90%. LCMS (pos) m/z 395.0, 397.0.

Sources & evidence

ORD record
ord-ca1fe67636b142f5acd866f3fe00a747
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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