4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10227532, compound

HRID 1435633Notes

Reaction equation

HRID 1435633 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[C:15]([C:31]#[N:32])=[C:16]([CH:28]=[CH:29][CH:30]=1)[O:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[Cl:13][C:14]1[C:15]([C:31]#[N:32])=[C:16]([CH:28]=[CH:29][CH:30]=1)[O:17][C:18]1[CH:19]=[CH:20][C:21]([S:24]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:25])=[O:26])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27769174-(3-Chloro-2-cyanophenoxy)benzenesulfonyl chloride

Product 1

HCID 10227532HCID 10227532, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-(3-chloro-2-cyanophenoxy)benzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (41.4 mg) with purity >90%. LCMS (pos) m/z 478.0.

Sources & evidence

ORD record
ord-c083a07bec55407eb60a160644f1b99e
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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