Benzenesulfonyl chloride, 3,4-dichloro- → HCID 10294071, compound

HRID 1435634Notes

Reaction equation

HRID 1435634 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:15]=[C:16]([S:21](Cl)(=[O:23])=[O:22])[CH:17]=[CH:18][C:19]=1[Cl:20]>>[Cl:13][C:14]1[CH:15]=[C:16]([S:21]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:23])[CH:17]=[CH:18][C:19]=1[Cl:20]

Participants

3

Reactant 2

HCID 7383Benzenesulfonyl chloride, 3,4-dichloro-HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10294071HCID 10294071, compound

Procedure

The tide compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3,4-dichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (50.1 mg) with purity >90%. LCMS (pos) m/z 395.0, 397.0.

Sources & evidence

ORD record
ord-d53279cf796345b1af96c157add1a6b4
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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