8-Quinolinesulfonyl chloride → HCID 10199594, compound

HRID 1435638Notes

Reaction equation

HRID 1435638 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][C:21]=2[S:23](Cl)(=[O:25])=[O:24])[CH:16]=[CH:15][CH:14]=1>>[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][C:21]=2[S:23]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:25])=[O:24])[CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 292208-Quinolinesulfonyl chlorideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10199594HCID 10199594, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 8-quinolinesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (9.2 mg) with purity >80%. LCMS (pos) m/z 378.2.

Sources & evidence

ORD record
ord-e85bf35ff8154f41a63856452eb86db8
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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