4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10221751, compound

HRID 1435639Notes

Reaction equation

HRID 1435639 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([S:23](Cl)(=[O:25])=[O:24])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([S:23]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:24])=[O:25])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27341833,4-Dimethoxybenzenesulfonyl chloride

Product 1

HCID 10221751HCID 10221751, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3,4-dimethoxybenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (19.3 mg) with purity >90%. LCMS (pos) m/z 387.2.

Sources & evidence

ORD record
ord-f685f8260474400fa0b85d489bbc1c47
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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