4-Iodobenzenesulfonyl chloride → HCID 10297744, compound

HRID 1435640Notes

Reaction equation

HRID 1435640 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH:13]1[C:18]([S:19](Cl)(=[O:21])=[O:20])=[CH:17][CH:16]=[C:15]([I:23])[CH:14]=1>>[I:23][C:15]1[CH:14]=[CH:13][C:18]([S:19]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:21])=[O:20])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 73994-Iodobenzenesulfonyl chlorideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10297744HCID 10297744, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and pipsyl chloride as described in the synthetic METHOD B to give a white solid (47.0 mg) with purity >90%. LCMS (pos) m/z 453.0.

Sources & evidence

ORD record
ord-ac6e2514c7ca4e7bbd624ac09dd75c18
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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