Dansyl chloride → HCID 10112799, compound

HRID 1435642Notes

Reaction equation

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[S:13](Cl)([C:16]1[C:28]2[CH:27]=[CH:26][CH:25]=[C:21]([N:22]([CH3:24])[CH3:23])[C:20]=2[CH:19]=[CH:18][CH:17]=1)(=[O:15])=[O:14]>>[CH3:23][N:22]([CH3:24])[C:21]1[CH:25]=[CH:26][CH:27]=[C:28]2[C:20]=1[CH:19]=[CH:18][CH:17]=[C:16]2[S:13]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:15])=[O:14]

Participants

Reactant 2

HCID 11801Dansyl chloride

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10112799HCID 10112799, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and dansyl chloride as described in the synthetic METHOD B to give a yellow solid (10.0 mg) with purity >90%. LCMS (pos) m/z 420.2.

Sources & evidence

ORD record: ord-4b206ba2afc245309d6c2c8acb8dfe14
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07618961B2

Reaction notes

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