4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 2814006, compound

HRID 1435643Notes

Reaction equation

HRID 1435643 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][N:14]1[CH:18]=[C:17]([S:19](Cl)(=[O:21])=[O:20])[N:16]=[CH:15]1>>[CH3:13][N:14]1[CH:18]=[C:17]([S:19]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:21])=[O:20])[N:16]=[CH:15]1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27368871-methyl-1H-imidazole-4-sulfonyl chloride

Product 1

HCID 2814006HCID 2814006, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 1-methylimidazole-4-sulfonyl chloride as described in the synthetic METHOD B to give a white solid (3.2 mg) with purity >90%. LCMS (pos) m/z 331.0.

Sources & evidence

ORD record
ord-7f11ae5e15b24e839f36e00407b456ee
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…