2-Naphthalenesulfonyl chloride → Ethyl {2-[(2-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetate

HRID 1435646Notes

Reaction equation

HRID 1435646 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[S:23](Cl)(=[O:25])=[O:24]>>[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[S:23]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:24])=[O:25]

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 1101317Ethyl {2-[(2-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-naphthalenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (41.2 mg) with purity >90%. LCMS (pos) m/z 377.2.

Sources & evidence

ORD record
ord-9bbf6494ec7444d99df453d2e415788e
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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