4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl (2-{[(3-bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

HRID 1435648Notes

Reaction equation

HRID 1435648 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Br:13][C:14]1[CH:18]=[C:17]([Cl:19])[S:16][C:15]=1[S:20](Cl)(=[O:22])=[O:21]>>[Br:13][C:14]1[CH:18]=[C:17]([Cl:19])[S:16][C:15]=1[S:20]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27374003-Bromo-5-chlorothiophene-2-sulfonyl chloride

Product 1

HCID 10203972Ethyl (2-{[(3-bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3-bromo-5-chlorothiophene-2-sulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (29.0 mg) with purity >90%. MS (pos) m/z 445.0, 447.0.

Sources & evidence

ORD record
ord-846184d278cd466f8411296caa455efb
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…