4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10139798, compound

HRID 1435649Notes

Reaction equation

HRID 1435649 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:13]([NH:21][CH2:22][C:23]1[S:27][C:26]([S:28](Cl)(=[O:30])=[O:29])=[CH:25][CH:24]=1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:13]([NH:21][CH2:22][C:23]1[S:27][C:26]([S:28]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:29])=[O:30])=[CH:25][CH:24]=1)(=[O:20])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27788785-(Benzamidomethyl)thiophene-2-sulfonyl chloride

Product 1

HCID 10139798HCID 10139798, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 5-[(benzoylamino)methyl]thiophene-2-sulfonyl chloride as described in the synthetic METHOD B to give a white solid (8.6 mg) with purity >70%. MS (pos) m/z 466.2.

Sources & evidence

ORD record
ord-35ea0d7ba1c24a3082a21c288b6bd3b7
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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