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4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl {2-[({5-[2-(methylsulfanyl)-4-pyrimidinyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Thiazoleacetic acid, 2-amino-, ethyl ester | HCID 104454 | — |
| 反応物 | 5-(2-(Methylthio)-4-pyrimidinyl)-2-thiophenesulfonyl chloride | HCID 2736995 | — |
| 生成物 | Ethyl {2-[({5-[2-(methylsulfanyl)-4-pyrimidinyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate | HCID 10115258 | — |
反応手順
The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 5-[2-(methylthio)pyrimidin-4-yl]thiophene-2-sulfonyl chloride as described in the synthetic METHOD B to give a white solid (34.5 mg) with purity >90%. MS (pos) m/z 475.3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07618961B2 |
| 出典データセット | uspto-grants-2009_11 |
| ORD ID | ord-750e8d3bccc5492d973356b02e800870 |
| 出典メモ | uspto-grants-2009_11 |