2,4,5-Trichlorobenzenesulfonyl chloride → Ethyl (2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

HRID 1435653Notes

Reaction equation

HRID 1435653 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[C:17]([Cl:21])=[CH:16][C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[C:17]([Cl:21])=[CH:16][C:15]=1[S:22]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 275752,4,5-Trichlorobenzenesulfonyl chlorideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10159741Ethyl (2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2,4,5-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (51.0 mg) with purity >90%. MS (pos) m/z 429.0. 431.0.

Sources & evidence

ORD record
ord-f0aa660029a144b2816b5f18862c8bfd
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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