4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 9924641, compound

HRID 1435654Notes

Reaction equation

HRID 1435654 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH:13]([S:21](Cl)(=[O:23])=[O:22])=[CH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:15]1(/[CH:14]=[CH:13]/[S:21]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:23])=[O:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 107500Ethenesulfonyl chloride, 2-phenyl-

Product 1

HCID 9924641HCID 9924641, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and beta-styrenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (21.3 mg) with purity >90%. MS (pos) m/z 353.1.

Sources & evidence

ORD record
ord-25fedaf1463e4d6f9089fe3dca100073
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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