4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10112220, compound

HRID 1435657Notes

Reaction equation

HRID 1435657 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:13][C:14]([F:27])([F:26])[O:15][C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1>>[F:27][C:14]([F:13])([F:26])[O:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:24])=[O:23])=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 523102p-(Trifluoromethoxy)benzenesulphonyl chloride

Product 1

HCID 10112220HCID 10112220, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-(trifluoromethoxy)benzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (29.1 mg) with purity >90%. MS (pos) m/z 411.1.

Sources & evidence

ORD record
ord-0fb37f70536e4c9a8d13954cec675a56
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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