4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10179405, compound

HRID 1435659Notes

Reaction equation

HRID 1435659 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Br:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20](Cl)(=[O:22])=[O:21]>>[Br:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 5204032-Bromobenzenesulfonyl chloride

Product 1

HCID 10179405HCID 10179405, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-bromobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (41.9 mg) with purity >90%. MS (pos) m/z 405.1, 407.1.

Sources & evidence

ORD record
ord-11f05df836e94c1b8679a8ee5f2cb850
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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