4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl (2-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

HRID 1435660Notes

Reaction equation

HRID 1435660 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[S:15][C:16]([S:20](Cl)(=[O:22])=[O:21])=[CH:17][C:18]=1[Cl:19]>>[Cl:19][C:18]1[CH:17]=[C:16]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:21])[S:15][C:14]=1[Cl:13]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 5186224,5-Dichlorothiophene-2-sulfonyl chloride

Product 1

HCID 10135654Ethyl (2-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2,3-dichlorothiophene-5-sulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (36.9 mg) with purity >90%. MS (pos) m/z 401.1, 403.1.

Sources & evidence

ORD record
ord-4bb21bded8fa46d683269d11ee0fe876
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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