4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl [2-({[4-(phenylsulfonyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate

HRID 1435661Notes

Reaction equation

HRID 1435661 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:13]1([S:19]([C:22]2[CH:23]=[C:24]([S:27](Cl)(=[O:29])=[O:28])[S:25][CH:26]=2)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([S:19]([C:22]2[CH:23]=[C:24]([S:27]([NH:1][C:2]3[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=3)(=[O:28])=[O:29])[S:25][CH:26]=2)(=[O:21])=[O:20])[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 6255744-(Benzenesulfonyl)thiophene-2-sulfonyl chloride

Product 1

HCID 10140202Ethyl [2-({[4-(phenylsulfonyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-benzenesulfonylthiophene-2-sulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (29.5 mg) with purity >90%. MS (pos) m/z 473.1.

Sources & evidence

ORD record
ord-5c53a75cc2bf47318c38eb7721cfd736
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…