4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10271999, compound

HRID 1435662Notes

Reaction equation

HRID 1435662 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=1[S:21](Cl)(=[O:23])=[O:22]>>[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:23])=[O:22]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 5221832,6-Dichlorobenzenesulfonylchloride

Product 1

HCID 10271999HCID 10271999, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2,6-dichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (32.5 mg) with purity >90%. MS (pos) m/z 395.1, 397.1.

Sources & evidence

ORD record
ord-5e8714ce11d14954984d7a68e83d726c
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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