4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 9903077, compound

HRID 1435663Notes

Reaction equation

HRID 1435663 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21](Cl)(=[O:23])=[O:22])#[N:14]>>[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:23])=[O:22])#[N:14]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 5223472-Cyanobenzenesulfonyl Chloride

Product 1

HCID 9903077HCID 9903077, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-cyanobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (24.6 mg) with purity >90%. MS (pos) m/z 352.2.

Sources & evidence

ORD record
ord-5527efc554da410fbf3c7fa2063ae9b7
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…