4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10136757, compound

HRID 1435664Notes

Reaction equation

HRID 1435664 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:13]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][C:18]=1[Cl:27])(=[O:15])[CH3:14]>>[C:13]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:25])=[O:24])=[CH:19][C:18]=1[Cl:27])(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 2827493-Chloro-4-acetamidobenzene-1-sulfonyl chloride

Product 1

HCID 10136757HCID 10136757, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-acetamido-3-chlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (16.1 mg) with purity >90%. MS (pos) m/z 418.2, 420.2.

Sources & evidence

ORD record
ord-61cd57c81ee94828915b6c52c0b92e23
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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