4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 9969941, compound

HRID 1435665Notes

Reaction equation

HRID 1435665 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[N:18]([CH3:19])[N:17]=[C:16]([CH3:20])[C:15]=1[S:21](Cl)(=[O:23])=[O:22]>>[Cl:13][C:14]1[N:18]([CH3:19])[N:17]=[C:16]([CH3:20])[C:15]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:22])=[O:23]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27771265-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride

Product 1

HCID 9969941HCID 9969941, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 5-chloro-1,3-dimethylpyrazole-4-sulfonyl chloride as described in the synthetic METHOD B to give a white solid (14.8 mg) with purity >90%. MS (pos) m/z 397.2, 381.2.

Sources & evidence

ORD record
ord-32b028c9c01a4a2fa0feb01151786bcb
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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