4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10291783, compound

HRID 1435666Notes

Reaction equation

HRID 1435666 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([S:21](Cl)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1>>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([S:21]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:23])=[O:22])[CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27375043-Methoxybenzenesulfonyl chloride

Product 1

HCID 10291783HCID 10291783, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3-methoxybenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (18.6 mg) with purity >90%. LCMS (pos) m/z 357.0.

Sources & evidence

ORD record
ord-1c03206706c34e01ae9eacb2bc1e8d9d
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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