4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10138501, compound

HRID 1435667Notes

Reaction equation

HRID 1435667 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Br:13][C:14]1[CH:15]=[C:16]([S:20](Cl)(=[O:22])=[O:21])[S:17][C:18]=1[Cl:19]>>[Br:13][C:14]1[CH:15]=[C:16]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:21])[S:17][C:18]=1[Cl:19]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27972204-Bromo-5-chlorothiophene-2-sulfonyl chloride

Product 1

HCID 10138501HCID 10138501, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-bromo-5-chlorothiophene-2-sulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (40.9 mg) with purity >90%. MS pos) m/z 445.0, 447.0.

Sources & evidence

ORD record
ord-c26da34559d74f69adf2107abbb549f6
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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