4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10179369, compound

HRID 1435670Notes

Reaction equation

HRID 1435670 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23](Cl)(=[O:25])=[O:24])(=[O:16])=[O:15]>>[CH3:13][S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:25])=[O:24])(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27351782-Methanesulfonylbenzene-1-sulfonyl chloride

Product 1

HCID 10179369HCID 10179369, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-methylsulfonylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (28.4 mg) with purity >90%. MS (pos) m/z 405.4.

Sources & evidence

ORD record
ord-a40049d552cd47958e6c6b0d33209218
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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