4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10202501, compound

HRID 1435671Notes

Reaction equation

HRID 1435671 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[C:16]([F:24])[CH:15]=1>>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:21])=[O:22])=[C:16]([F:24])[CH:15]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27363104-Bromo-2-fluorobenzene-1-sulfonyl chloride

Product 1

HCID 10202501HCID 10202501, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-bromo-2-fluorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (15.1 mg) with purity >90%. MS (pos) m/z 423.3, 425.3.

Sources & evidence

ORD record
ord-ba2f907fbefd44c9ab82325a4f2f3f0e
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…