4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10135762, compound

HRID 1435673Notes

Reaction equation

HRID 1435673 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[C:22]2[C:18](=[N:19][O:20][N:21]=2)[C:17]([S:23](Cl)(=[O:25])=[O:24])=[CH:16][CH:15]=1>>[Cl:13][C:14]1[C:22]2=[N:21][O:20][N:19]=[C:18]2[C:17]([S:23]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:24])=[O:25])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 6125157-Chloro-2,1,3-benzoxadiazole-4-sulfonyl chloride

Product 1

HCID 10135762HCID 10135762, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-chloro-7-chlorosulfonyl-2,1,3-benzoxadiazole as described in the synthetic METHOD B to give a yellow solid (2.5 mg) with purity >90%. MS (pos) m/z 403.4.

Sources & evidence

ORD record
ord-85629e6987474b1ba931467f3cfdd1eb
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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