4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10155810, compound

HRID 1435676Notes

Reaction equation

HRID 1435676 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[S:18][C:17]([S:19](Cl)(=[O:21])=[O:20])=[CH:16][CH:15]=1>>[Cl:13][C:14]1[S:18][C:17]([S:19]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:21])=[O:20])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27339255-Chlorothiophene-2-sulfonyl chloride

Product 1

HCID 10155810HCID 10155810, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 5-chlorothiophene-2-sulfonyl chloride as described in the synthetic METHOD B to give a white solid (24.3 mg) with purity >90%. MS (pos) m/z 367.1, 369.1.

Sources & evidence

ORD record
ord-5fd749bcbda14ff48c99acfddefe011d
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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