4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10113094, compound

HRID 1435681Notes

Reaction equation

HRID 1435681 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][C:14]1[CH:19]=[C:18]([O:20][C:21]([F:24])([F:23])[F:22])[CH:17]=[CH:16][C:15]=1[S:25](Cl)(=[O:27])=[O:26]>>[CH3:13][C:14]1[CH:19]=[C:18]([O:20][C:21]([F:22])([F:23])[F:24])[CH:17]=[CH:16][C:15]=1[S:25]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 22272473HCID 22272473, compound

Product 1

HCID 10113094HCID 10113094, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-methyl-4-trifluoromethoxybenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (41.7 mg) with purity >90%. MS (pos) m/z 425.3.

Sources & evidence

ORD record
ord-f414a7e53baf49079d2757391aca8b84
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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