4-N-Propylbenzenesulphonyl chloride → HCID 10271250, compound

HRID 1435682Notes

Reaction equation

HRID 1435682 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH2:14]([C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1)[CH2:15][CH3:16]>>[O:13]=[C:7]([C:5]1[N:6]=[C:2]([NH:1][S:23]([C:20]2[CH:21]=[CH:22][C:17]([CH2:14][CH2:15][CH3:16])=[CH:18][CH:19]=2)(=[O:25])=[O:24])[S:3][CH:4]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 27372224-N-Propylbenzenesulphonyl chlorideHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 10271250HCID 10271250, compound

Procedure

The title compound was prepared from ethyl (2-amino-4-thiazolyl)glyoxylate and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (14.5 mg) with purity >90%. LCMS (pos) m/z 383.2.

Sources & evidence

ORD record
ord-7652003e413f48a28cfba88cb945fd6b
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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