(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 86594951, compound

HRID 1435686Notes

Reaction equation

HRID 1435686 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:12])=[C:5]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[N:6]=1.[C:13]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>>[C:13]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:16]([S:19]([NH:1][C:2]2[S:3][C:4]([CH3:12])=[C:5]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[N:6]=2)(=[O:21])=[O:20])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 2763571Methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate

Product 1

HCID 86594951HCID 86594951, compound

Procedure

The title compound was prepared from methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate and 4-biphenylsulfonyl chloride as described in the synthetic METHOD B to give a white solid (22:1 mg) with purity >90%. LCMS (pos) m/z 403.0.

Workup

  1. customto give a white solid (22:1 mg) with purity >90%

Sources & evidence

ORD record
ord-073fd151cf8f4b2f818f2d44c0df2b3a
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…