Methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate → Methyl [2-({[4-(3-chloro-2-cyanophenoxy)phenyl]sulfonyl}amino)-5-methyl-1,3-thiazol-4-yl]acetate

Participants

Role	Name	HCID	Charge
Reactant	Methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate	HCID 2763571	—
Reactant	4-(3-Chloro-2-cyanophenoxy)benzenesulfonyl chloride	HCID 2776917	—
Product	Methyl [2-({[4-(3-chloro-2-cyanophenoxy)phenyl]sulfonyl}amino)-5-methyl-1,3-thiazol-4-yl]acetate	HCID 86594954	—

Reaction Steps

The title compound was prepared from methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate and 4-(3-chloro-2-cyanophenoxy)benzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (28.3 mg) with purity >90%. LCMS (pos) m/z 478.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07618961B2
Source dataset	uspto-grants-2009_11
ORD ID	ord-1dd8226d96964b87b2513c45c5d9531f
Source note	uspto-grants-2009_11