Formaldehyde → HCID 87546257, compound

Participants

Reaction Steps

A solution of EXAMPLE 182A (360 mg, 1 mmol), dimethylamine hydrochloride (164 mg, 2 mmol), 37% formaldehyde (0.5 mL) in acetic acid (5 mL) was heated at 100° C. for 5.5 hrs. The solvent was evaporated. The residue was dissolved in water (5 mL). The pH of the water solution was adjusted to 9 with 2 N NaOH. The precipitate was filtered, washed with water and dried to give the product as white powder (115.4 mg, 28% yield): mp 152-153° C.; MS m/e, 420, 418 (M+)

Provenance & Evidence