HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → cis-3-(1H-indol-3-yl)-indan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 3-(1H-indol-3-yl)-indan-1-one | HCID 68895061 | — |
| Reactant | Racemic cis-3-indolyl-indan-1-ol | HCID 68915444 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | cis-3-(1H-indol-3-yl)-indan-1-ol | HCID 68910747 | — |
Reaction Steps
NaBH4 (6.2 g, 163 mmol, 2 equiv.) was added to 3-(1H-indol-3-yl)-indan-1-one (20 g, 80.9 mmol ) in 200 mL methanol and 100 mL THF at 0° C. The reaction mixture was allowed to warm to room temperature over night. Aqueous work up gave racemic cis-3-indolyl-indan-1-ol (quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618967B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-d2eaee945d534e35b61923ac1d864e4f |
| Source note | uspto-grants-2009_11 |