Ethyl Acetate → HCID 68895059, compound

Participants

Reaction Steps

Dess-Martin Periodane (1.08 g, 2.55 mmol ) in 10 mL CH2Cl2 was added to (1S,3R)-3-(1H-Indol-3-yl)-indan-1-ol (2.52 mmol ) in 10 mL CH2Cl2 at 0° C. The reaction mixture was allowed to warm to room temperature and stirred 40 min—TLC showed full conversion. To the reaction mixture ethyl acetate and sat. NaHCO3 was added. The organic phase was isolated, washed with 2N NaOH and brine, dried over MgSO4 and concentrated in vacuo. A quantitative yield of (R)-3-(1H-indol-3-yl)-indan-1-one was obtained after flash chromatography (heptane/ethyl acetate, silica gel).

Provenance & Evidence