Methylamine → HCID 24887103, compound

Participants

Reaction Steps

(R)-3-(1H-indol-3-yl)-indan-1-one, methyl amine (5 mL 2M in THF) and 1 mL tetraethoxy silane in 10 mL methanol were stirred 11 minutes at 150° C. under microwave irradiation using the Emry Optimizer™ instrument. PtO2 (10 mg) was added and the reaction mixture was stirred under 1 atm. hydrogen over night at room temperature, filtered and concentrated in vacuo. [(1S,3R)-3-(1H-Indol-3-yl)-indan-1-yl]-methyl-amine was isolated in 66% yield after flash chromatography (ethyl acetate, methanol, triethylamine, silica gel).

Provenance & Evidence