(2R,3R)-2,3-dihydroxy-2,3-bis(4-methylbenzoyl)butanedioic acid → HCID 24748205, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the racemate cis-3-(7-Fluoro-1H-indol-3-yl)-indan-1-yl-methyl-amine (409 mg/2ml EtOH) was added a solution of Di-p-toluoyl-D-tartaric acid (1 eq; 564 mg/2 ml Acetone). The mixture was heated to 50° C. and stirred for 15min. Evaporated the solvent and triturated with acetone (2 ml). The white solid (84% ee) was collected and stirred with 10 ml hot EtOH for 30 min. The remaining white solid was collected and converted to free base to give [(1S,3R)-3-(7-Fluoro-1H-indol-3-yl)-indan-1-yl]-methyl-amine (93% ee).

Provenance & Evidence