反应详情

In a 3-necked flask, sildenafil (5 g, 10 mmol) and citric acid (2 g, 10 mmol) were suspended in acetone (100 ml). The reaction mixture was heated to reflux and maintained at reflux for 1 hour, thereafter, the reaction mixture was allowed to cool for 3 hours to room temperature. The precipitate was collected by filtration and dried at 50° C. under 10 mm Hg to give pure sildenafil citrate in 94.4% yield.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux
3. temperaturemaintained
4. temperatureat reflux for 1 hour
5. temperatureto cool for 3 hours to room temperature
6. filtrationThe precipitate was collected by filtration
7. customdried at 50° C. under 10 mm Hg