HCID 86594994, compound → Methyl 4-(methylsulfanyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

HRID 1435885Notes

Reaction equation

HRID 1435885 reaction equation
[N:1](/[C:4](=[CH:9]\[C:10]1[C:11]([S:16][CH3:17])=[N:12][CH:13]=[CH:14][CH:15]=1)/[C:5]([O:7][CH3:8])=[O:6])=[N+]=[N-]>C1(C)C=C(C)C=C(C)C=1>[CH3:17][S:16][C:11]1[C:10]2[CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[NH:1][C:15]=2[CH:14]=[CH:13][N:12]=1

Participants

3

Reactant 1

HCID 86594994HCID 86594994, compound

Product 1

HCID 37818542Methyl 4-(methylsulfanyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 7947MesityleneSolvent

Procedure

A solution of methyl (2Z)-2-azido-3-[2-(methylthio)pyridin-3-yl]prop-2-enoate (1.00 g, 4.00 mmol) in mesitylene (50 mL) was heated at 160° C. for a period of 1 h. The reaction mixture was cooled to room temperature then to 0° C., the precipitate was filtered and washed with cold mesitylene to provide the title compound.

Workup

  1. filtrationto 0° C., the precipitate was filtered
  2. washwashed with cold mesitylene

Sources & evidence

ORD record
ord-7b8b859217984d659ae9570d0b70b662
Source dataset
uspto-grants-2009_11
Patent number
US07618979B2

Reaction notes

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