Methyl bromoacetate → HCID 86601996, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(methylthio)-6,7-dihydro-8H-pyrido[3,4-b]pyrrolizin-8-one (0.15 g, 0.68 mmol), methyl bromoacetate (0.34 mL), Zn—Cu (0.226 g) in THF (3.0 mL) was sonicated for 2 h. The mixture was then heated at 60° C. for 5 min. until completion of the reaction. The reaction mixture was partitioned between EtOAc and NH4Cl. The organic phase was separated, dried over Na2SO4, filtered and evaporated under reduced pressure to provide the title compound. The compound was purified by flash chromatography.

Provenance & Evidence