Sodium Iodide → HCID 86601997, compound

Participants

Reaction Steps

To NaI (0.300 g) in CH3CN (3.2 mL) was added TMSCl (0.266 mL). This mixture was added to a suspension of methyl [8-hydroxy-1-(methylthio)-7,8-dihydro-6H-pyrido[3,4-b]pyrrolizin-8-yl]acetate (0.15 g, 0.515 mmol) in CH3CN (1.5 mL), in a water bath. After a period of 0.5 h, the reaction mixture was partitioned between EtOAc and NaHCO3. The organic phase was separated, washed with sodium thiosulphate, dried over MgSO4 and evaporated. The title compound was purified by flash chromatography.

Provenance & Evidence