Ethyl Acetate → Ethyl (2E)-(1-isopropenyl-6,7-dihydro-8H-pyrido[3,4-b]pyrrolizin-8-ylidene)ethanoate

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-isopropenyl-6,7-dihydro-8H-pyrido[3,4-b]pyrrolizin-8-one (0.60 g, 2.8 mmol) and triethyl phosphonoacetate (1.00 g, 4.46 mmol) in THF (24 mL) at −78° C. was added 80% NaH (0.12 g, 4.00 mmol), the reaction mixture was allowed to warm to 0° C., then to room temperature. The reaction mixture was poured onto saturated NH4Cl and EtOAc. The organic phase was separated, dried over Na2SO4 and evaporated. The title compound was purified by flash chromatography (40% EtOAc in Hexane).

Provenance & Evidence