HCID 15524163, compound → HCID 9906468, compound

HRID 1435903Notes

Reaction equation

HRID 1435903 reaction equation
C(OC([NH:8][C:9]1[CH:10]=[C:11]([S:15]([NH2:18])(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1)=O)(C)(C)C.[Cl:19][C:20]1[CH:21]=[C:22]([NH:30][C:31](OC2C=CC=CC=2)=[O:32])[C:23](=[CH:28][CH:29]=1)[C:24](OC)=[O:25]>>[NH2:8][C:9]1[CH:10]=[C:11]([S:15]([N:18]2[C:24](=[O:25])[C:23]3[C:22](=[CH:21][C:20]([Cl:19])=[CH:29][CH:28]=3)[NH:30][C:31]2=[O:32])(=[O:16])=[O:17])[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 15524163HCID 15524163, compoundHCID 22347476HCID 22347476, compound

Product 1

HCID 9906468HCID 9906468, compoundYield 49%

Procedure

3.5 g (12.9 mmol) of 3-t-butoxycarbonylamino-benzenesulfonamide and 3.9 g (12.8 mmol) of methyl 4-chloro-2-N-phenoxycarbonylanthranilate were treated in the same way as in Preparation Example 7 to obtain 2.2 g (yield 49%: 4 steps) of the above-identified compound. Properties: colorless crystal, Melting point: >200° C. (decomposition), PMR (δ ppm, DMSO-d6): 5.72 (2H, s), 6.87 (1H, d), 7.12 (1H, s), 7.23-7.27 (2H, m), 7.33 (1H, S), 7.86 (1H, d), 11.61 (1H, s).

Workup

  1. customto obtain 2.2 g (yield 49%: 4 steps) of the above-identified compound

Sources & evidence

ORD record
ord-6992fd2a12474a1e8127e39c47fb11c3
Source dataset
uspto-grants-2009_11
Patent number
US07618977B2

Reaction notes

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