HCID 22347456, compound → HCID 9821064, compound

HRID 1435916Notes

Reaction equation

HRID 1435916 reaction equation
C(OC([NH:11][C:12]1[CH:13]=[C:14]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:15]=[CH:16][C:17]=1[C:18]([O:20]C(C)(C)C)=[O:19])=O)C1C=CC=CC=1.[OH:29][C:30]1[CH:31]=[C:32]([NH:46][C:47](OC2C=CC=CC=2)=[O:48])[C:33](=[CH:44][CH:45]=1)[C:34](OCC1C=CC=CC=1)=[O:35]>>[OH:29][C:30]1[CH:31]=[C:32]2[C:33]([C:34](=[O:35])[N:28]([S:25]([C:14]3[CH:13]=[C:12]([NH2:11])[C:17](=[CH:16][CH:15]=3)[C:18]([OH:20])=[O:19])(=[O:26])=[O:27])[C:47](=[O:48])[NH:46]2)=[CH:44][CH:45]=1

Participants

3

Reactant 2

HCID 22347456HCID 22347456, compoundHCID 22347462HCID 22347462, compound

Product 1

HCID 9821064HCID 9821064, compoundYield 4%

Procedure

620 mg (1.53 mmol) of 3-benzyloxycarbonylamino-4-t-butoxycarbonylbenzenesulfonamide and 550 mg (1.51 mmol) of benzyl 4-hydroxy-2-N-phenoxycarbonylanthranilate were treated in the same way as in Preparation Example 17 to obtain 25 mg (yield 4%: 4 steps) of the above-identified compound. Properties: colorless crystal, Melting point: >200° C. (decomposition), PMR (δ ppm, DMSO-d6): 6.48 (1H, s), 6.61 (1H, d), 7.14 (1H, d), 7.51 (1H, s), 7.70 (1H, d), 7.90 (1H, d), 10.80 (1H, s), 11.39 (1H, s).

Workup

  1. customto obtain 25 mg (yield 4%: 4 steps) of the above-identified compound

Sources & evidence

ORD record
ord-51e90ae2ec76458aa4e02455fb1b05ac
Source dataset
uspto-grants-2009_11
Patent number
US07618977B2

Reaction notes

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