HCID 22347436, compound → HCID 9930602, compound

HRID 1435918Notes

Reaction equation

HRID 1435918 reaction equation
C(OC([NH:11][C:12]1[CH:13]=[C:14]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:15]=[CH:16][C:17]=1[C:18]([O:20]C(C)(C)C)=[O:19])=O)C1C=CC=CC=1.[Cl:29][C:30]1[CH:45]=[C:34]([C:35](OCC2C=CC=CC=2)=[O:36])[C:33]([NH:46][C:47](OC2C=CC=CC=2)=[O:48])=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:45]=[C:34]2[C:33](=[CH:32][CH:31]=1)[NH:46][C:47](=[O:48])[N:28]([S:25]([C:14]1[CH:13]=[C:12]([NH2:11])[C:17](=[CH:16][CH:15]=1)[C:18]([OH:20])=[O:19])(=[O:26])=[O:27])[C:35]2=[O:36]

Participants

3

Reactant 2

HCID 22347436HCID 22347436, compoundHCID 22347462HCID 22347462, compound

Product 1

HCID 9930602HCID 9930602, compoundYield 26%

Procedure

300 mg (0.74 mmol) of 3-benzyloxycarbonylamino-4-t-butoxycarbonylbenzenesulfonamide and 310 mg (0.81 mmol) of benzyl 5-chloro-2-N-phenoxycarbonylanthranilate were treated in the same way as in Preparation Example 17 to obtain 75 mg (yield 26%: 4 steps) of the above-identified compound. Properties: colorless crystal, Melting point: >200° C. (decomposition), PMR (δ ppm, DMSO-d6): 7.13-7.20 (2H, m), 7.56 (1H, s), 7.72 (1H, d), 7.82 (1H, s), 7.90 (1H, d), 11.68 (1H, s).

Workup

  1. customto obtain 75 mg (yield 26%: 4 steps) of the above-identified compound

Sources & evidence

ORD record
ord-11612f7f8eb84cee9abfa651cd7b8480
Source dataset
uspto-grants-2009_11
Patent number
US07618977B2

Reaction notes

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