Dimethylformamide → HCID 68971616, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (±)-cis tert-butyl 6-methoxy-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]quinoline-2(9bH)-carboxylate from Example 10, Part B (0.39 g, 1.28 mmol) in 8 mL of THF and 4 mL of DMF at −30° C. was added N-bromosuccinimide (0.15 g, 1.34 mmol). The reaction was stirred at −30° C. for 1 h and then was diluted with water and ethyl acetate. The organics were washed with water and brine, dried (Na2SO4) and concentrated in vacuo to afford 0.41 g (83%) of the title compound which was used without purification.

Provenance & Evidence