2-(Trifluoromethyl)benzeneboronic acid → HCID 11551992, compound

Participants

Reaction Steps

Following the procedures described in Example 12, except that 2-(trifluoromethyl)phenylboronic acid was used instead of phenylboronic acid, (±)-cis-tert-butyl 8-bromo-6-methoxy-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]quinoline-2(9bH)-carboxylate from Example 11, Part A was converted into the title compound of Example 13. 1H NMR (CDCl3): δ 7.73 (d, 1H, J=7.7 Hz), 7.57-7.52 (m, 1H), 7.46-7.40 (m, 1H), 7.36 (d, 1H, J=7.4 Hz), 6.68 (s, 1H), 6.66 (s, 1H), 4.51 (broad s, 1H), 3.85 (s, 3H), 3.65-3.30 (overlapping m, 5H), 3.15-2.98 (m, 2H), 2.78-2.68 (m, 1H). LRMS (ES)+: 349.3 (M+H)+.

Provenance & Evidence