Dimethylformamide → HCID 131727762, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (±)-cis tert-butyl 6-methyl-4-oxo-3,3a,4,5-tetrahydro-1H-pyrrolo[3,4-c]quinoline-2(9bH)-carboxylate from Example 19, Part A (0.87 g, 3.0 mmol) in 15 mL of THF and 4 mL of DMF at −30° C. was added N-bromosuccinimide (0.56 g, 3.15 mmol). The reaction was stirred at −30° C. for 1 h and then was diluted with water and ethyl acetate. The organics were washed with water and brine, dried (Na2SO4) and concentrated in vacuo to afford 0.99 g (90%) of the title compound which was used without purification.

Provenance & Evidence