HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-hydroxypiperidine-1-carboxylate → HCID 50942210, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | 1-Aminoisoquinolin-6-ol | HCID 135753991 | — |
| Product | HCID 50942210 | HCID 50942210 | 25.5% |
Reaction Steps
This compound was prepared from 4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (455 mg, 2.26 mmol) and 1-amino-6-hydroxyisoquinoline (435 mg, 2.71 mmol) by the Mitsunobu procedure described in 3C. Subsequent Boc deprotection according to procedure described in 3D gave 6-(piperidin-4-yloxy)-isoquinolin-1-ylamine (140 mg), EIMS: m/z=244.6 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618985B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-16afaeccc15d45618457ac38ee78ecff |
| Source note | uspto-grants-2009_11 |